Dynamic-clamp Analysis of Wild-type hNaV1.7 and Erythromelalgia Mutant Channel
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چکیده
2 3 Dynamic-clamp Analysis of Wild-type hNaV1.7 and Erythromelalgia Mutant Channel 4 L858H 5 6 Dmytro V. Vasylyev, Chongyang Han, Peng Zhao, Sulayman Dib-Hajj, Stephen G. Waxman 7 8 Department of Neurology and Center for Neuroscience & Regeneration Research, Yale 9 University School of Medicine, New Haven, CT 06510; Rehabilitation Research Center, 10 Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516 11 12 13 Running head: Mechanistic role of NaV1.7 in neuronal hyperexcitability 14 15 16 17 Correspondence should be addressed to: 18 Stephen G. Waxman, M.D., Ph.D. 19 Rehabilitation Research Center, 127A 20 Veteran Affairs Connecticut Healthcare System 21 950 Campbell Avenue, Building 34 22 West Haven, CT 06516 23 Tel: (203) 937-3802 24 Fax: (203) 937-3801 25 [email protected] 26 Articles in PresS. J Neurophysiol (January 8, 2014). doi:10.1152/jn.00763.2013
منابع مشابه
Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability
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The link between sodium channel Nav1.7 and pain has been strengthened by identification of gain-of-function mutations in patients with inherited erythromelalgia (IEM), a genetic model of neuropathic pain in humans. A firm mechanistic link to nociceptor dysfunction has been precluded because assessments of the effect of the mutations on nociceptor function have thus far depended on electrophysio...
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